Amitriptyline, Oral Tablet

FDA warning: Suicidal thoughts and conduct This drug has a black container warning. This is the maximum severe caution from the Food and Drug Administration (FDA). A black container caution alerts medical doctors…

Highlights for amitriptyline

  • Amitriptyline oral pill is to be had as a conventional drug. It’s now not to be had as a brand-call drug.
  • Amitriptyline comes best as a pill you’re taking by using the mouth.
  • Amitriptyline oral tablet is used to assist relieve signs of depression.

What is amitriptyline?

Amitriptyline is a prescription drug. It comes as a tablet you take through the mouth. Amitriptyline oral pill isn’t always available as a brand-call drug. It’s only to be had as an everyday drug. Generic drugs typically cost much less than brand-call pills.

Why it’s used?

Amitriptyline is used to assist relieve signs and symptoms of despair.

How it works

Amitriptyline belongs to a class of medication called tricyclic antidepressants. A class of medication is a group of medicinal drugs that work in a similar manner. These pills are often used to treat similar situations. Amitriptyline works for your significant nervous system to grow the level of positive chemicals for your brain, which improves your melancholy.

Amitriptyline aspect effects

Amitriptyline can cause dizziness and drowsiness during the primary few hours after you take it. If you notice drowsiness even as you take this drug, your physician may have you take your dose at bedtime. Amitriptyline can also reason other side consequences.

More common side results

The greater not unusual aspect results of amitriptyline can consist of:

  • confusion
  • numbness and tingling on your palms and legs
  • headache
  • constipation or diarrhea
  • blurred vision
  • pores and skin rash
  • swelling of your face and tongue
  • nausea
  • surprising weight benefit or loss

If these consequences are mild, they’ll leave within some days or a couple of weeks. If they’re more intense or don’t go away, talk to your doctor or pharmacist.

Serious side results

Call your physician proper away if you have serious side outcomes. Call 911 if your signs sense life-threatening or if you think you’re having a scientific emergency. Serious aspect outcomes and their symptoms can encompass the following:

  • Heart attack. Symptoms can encompass:
  • chest ache
  • shortness of breath
  • Pain or stress to your chest or upper body
  • Stroke. Symptoms can encompass:
  • the weak spot in one element or aspect of your body
  • slurred speech

Disclaimer: Our purpose is to provide you with the most relevant and current data. However, because pills affect every person differently, we cannot guarantee that this fact includes all feasible side results. This fact isn’t an alternative to clinical advice. Always talk feasible facet results with a healthcare company that knows your scientific history.

Amitriptyline might also have interaction with other medicines

Amitriptyline oral tablet can have interaction with other medications, vitamins, or herbs you’ll be taking. An interplay is when a substance adjustments the way a drug works. This may be dangerous or save you the drug from operating nicely. To help keep away from interactions, your medical doctor must manipulate all of your medicines carefully. Be positive to tell your medical doctor approximately all medicinal drugs, vitamins, or herbs you’re taking. To find out how this drug may have interaction with something else you’re taking, talk to your doctor or pharmacist. Examples of medications that can motive interactions with amitriptyline are indexed below.

Drugs you ought to now not take with amitriptyline

Taking sure tablets with amitriptyline may also reason critical facet outcomes. You have to no longer take these capsules and amitriptyline at the equal time. Examples of those tablets include:

  • Monoamine oxidase inhibitors (MAOIs). Examples of those pills encompass:
  • phenelzine
  • tranylcypromine
  • selegiline

Using an MAOI with amitriptyline can cause seizures or even death. Do now not take an MAOI within weeks of preventing amitriptyline, unless told to achieve this through your doctor. Also, do no longer begin taking amitriptyline if you stopped taking an MAOI within the final two weeks unless advised to do so by your physician. If you aren’t positive whether any of the drugs you’re taking is an MAOI, ask your medical doctor or pharmacist.

Quinidine. Taking this drug with amitriptyline should boom the quantity of amitriptyline in your body. This ought to cause risky aspect outcomes. Drugs that purpose more negative effects Taking amitriptyline with sure tablets raises your risk of negative results. Examples of these tablets consist of:

  • Topiramate. Taking this drug with amitriptyline could boom the quantity of amitriptyline on your frame. This increases your danger of side effects. Your physician may also modify your dosage of amitriptyline in case you take it with topiramate.
  • Sertraline, fluoxetine, and paroxetine. These capsules can grow the dangerous aspect effects of amitriptyline.
  • Cimetidine. Taking this drug with amitriptyline should increase the quantity of amitriptyline on your frame. This increases your threat of aspect outcomes.
  • Anticholinergic capsules. Examples include diphenhydramine, oxybutynin, solifenacin, and olanzapine.
  • Taking these drugs with amitriptyline increases your risk of side effects together with fever, specifically in the course of warm weather.
  • Neuroleptic tablets. Examples consist of clozapine, risperidone, and haloperidol. Taking these tablets with amitriptyline increases your threat of aspect effects along with fever, specifically during hot weather.

How to take amitriptyline

All possible dosages and drug forms won’t be included here. Your dosage, drug form, and how regularly you take the drug will rely on:

  • your age
  • the condition being treated
  • the severity of your condition
  • other scientific situations you have
  • the way you react to the first dose
  • Forms and strengths

Generic: Amitriptyline

Form: oral pill
Strengths: 10 mg, 25 mg, 50 mg, 75 mg, a hundred mg, one hundred fifty mg
Dosage for depression

Adult dosage (ages 18–sixty-four years)

  • Typical beginning dosage: seventy-five mg according to day, commonly in divided doses.
  • Dosage increases: Your physician will slowly boom your dosage if needed.
  • Maximum dosage: 150 mg in line with day.
  • Alternative dosage regimen: Start with 50 to 100 mg at bedtime. This may be accelerated by 25 or 50 mg as needed inside the bedtime dose, for a complete of a hundred and fifty mg in line with day.

Child dosage (ages 0–17 years)

It hasn’t been showed that amitriptyline is safe and powerful to be used in children more youthful than 17 years.

Senior dosage (ages sixty-five years and older)

The kidneys of older adults might not work in addition to they used to. This can cause your frame to process pills greater slowly. As a result, greater of a drug stays for your body for a longer time. This raises your risk of facet outcomes. Your health practitioner may start you on a lowered dose or a one-of-a-kind dosing schedule. This can assist hold degrees of this drug from building up too much on your frame.

Disclaimer: Our goal is to offer you the maximum relevant and current data. However, due to the fact tablets have an effect on each person differently, we can’t assure that this listing includes all possible dosages. This record isn’t an alternative choice to medical advice. Always communicate with your doctor or pharmacist about dosages that are right for you.

WHEN TO CALL THE DOCTORCall your health practitioner in case you be aware worsening depression or suicidal mind. Also, name your doctor proper away if you end up pregnant while taking this drug.


FDA caution: Suicidal thoughts and behavior This drug has a black box caution. This is the most serious caution from the Food and Drug Administration (FDA). A black box warning alerts docs and sufferers about drug consequences that can be risky. Amitriptyline can increase the risk of suicidal mind and behavior, especially in children, adolescents, and younger adults. People of all ages who are commenced on antidepressant therapy should be watched closely for signs and symptoms of adjustments in behavior or worsening depression.

Worsening despair caution

You would possibly experience an initial worsening of your depression, the mind of suicide, and behavioral changes whilst you first begin taking amitriptyline. This threat can also ultimate until the drug starts operating for you.

Withdrawal signs warning

If you’ve been taking this remedy for an extended time, you shouldn’t prevent taking it suddenly. Stopping it suddenly may also purpose aspect results including nausea, headache, and tiredness. Don’t prevent taking this drug without speak to your physician. They will inform you of the way to slowly decrease your dosage over time.

Dementia warning

ResearchTrusted Source has indicated that this type of medicinal drug can motive effects much like those brought about by way of drugs called anticholinergics. This can raise your hazard of dementia.

Allergy caution

This drug can cause excessive hypersensitivity. Symptoms can encompass:

  • pores and skin rash or hives
  • hassle breathing
  • swelling of your face or tongue

If you expand these signs, call 911 or go to the closest emergency room.

Don’t take this drug again if you’ve ever had a hypersensitivity to it. Taking it again will be fatal (reason death).

Alcohol interplay caution

The use of liquids that contain alcohol at the same time as taking amitriptyline raises your hazard of severe facet consequences, including severe drowsiness.

Warnings for human beings with positive health conditions

For human beings with coronary heart disorders: Taking this drug should reason heart problems, including abnormal coronary heart rhythm, heart attack, and stroke. Do not take this drug in case you’re getting better from the latest heart attack.

For humans with bipolar disorder: Before beginning you on remedy with antidepressants together with amitriptyline, it’s critical for your medical doctor to check your risk of bipolar disorder. Your medical doctor needs to do that because a prime depressive episode is typically the first symptom observed in human beings with bipolar disorder. This drug has to now not be used in humans with bipolar disorder.

For humans with a history of seizures: Taking this drug increases your danger of seizures. If you have records of seizures, your health practitioner will display you carefully even as you’re taking this drug. If you’ve got a seizure while taking this drug, prevent taking it and speak to your physician right away.

For human beings with records of glaucoma or extended eye stress: Taking this drug ought to increase the pressure on your eyes. If you have records of glaucoma or multiplied eye stress, your health practitioner will reveal you closely while you’re taking this drug.

Warnings for other groups

For pregnant women: Amitriptyline is a class C pregnancy drug. That way two things:

Research in animals has proven adverse consequences to the fetus while the mother takes the drug.
There hasn’t been sufficient research performed in humans to be certain how the drug may have an effect on the fetus.

Talk to your physician in case you’re pregnant or making plans to turn out to be pregnant. This drug should handiest be used if the potential advantage justifies the potential chance to the fetus.

For women who are breastfeeding: Amitriptyline passes into breast milk and can also cause facet results in a child who’s breastfed. Talk to your medical doctor if you breastfeed your child. You may also need to determine whether or not to stop breastfeeding or prevent taking this medicine.

For seniors: The kidneys of older adults won’t work as well as they used to. This can cause your body to procedure tablets more slowly. As a result, more of a drug stays in your body for a longer time. This raises your chance of side results. These side consequences encompass fast coronary heart rate, trouble urinating, constipation, dry mouth, and blurred vision.

For kids: It has no longer been confirmed that this drug is secure and powerful to be used in youngsters more youthful than 18 years. The use of this drug in children need to stability the potential dangers with the clinical need.

Take as directed

Amitriptyline oral tablet is used for long-term treatment. It comes with dangers if you don’t take it as prescribed.

If you forestall taking the drug unexpectedly or don’t take it at all: If you don’t take amitriptyline, your despair may additionally worsen. If you stop taking this remedy unexpectedly you may have withdrawal facet effects together with nausea, headache, and tiredness. If you leave out doses or don’t take the drug on schedule: Your medication won’t work as properly or might also forestall operating completely. For this drug to paintings nicely, a positive amount desires to be to your frame in any respect times. If you are taking an excessive amount of: You should have risky degrees of the drug in your body. Symptoms of an overdose of this drug can consist of:

  • irregular heart rhythm
  • severely low heart rate
  • convulsions
  • hallucinations
  • confusion
  • stiff muscles

Important issues for taking amitriptyline

Keep these issues in mind if your medical doctor prescribes amitriptyline for you.

  • General
  • You can take amitriptyline without or with food.
  • You can reduce or weigh down the pill.
  • Storage
  • Store Amitriptyline at room temperature between 68°F and 77°F (20°C and 25°C). It may be stored
  • for short periods among 59°F and 86°F (15°C and 30°C).
  • Keep this drug far from light.
  • Don’t keep this drug in moist or damp areas, inclusive of bathrooms.
  • Refills

A prescription for this remedy is refillable. You have to not want a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized to your prescription.


When traveling with your medicine:

Always deliver your medicinal drug with you. When flying, in no way positioned it right into a checked bag. Keep it in your convey-on bag.

Don’t worry about approximately airport X-ray machines. They can’t harm your remedy.

You may additionally want to show airport staff the drugstore label for your medicine. Always bring the unique prescription-labeled field with you.

Don’t place this medicinal drug on your car’s glove compartment or depart it within the car. Be certain to keep away from doing this whilst the weather may be very warm or very cold.

Clinical monitoring

Your health practitioner will screen your mental health whilst you are taking this drug. Be sure to inform your doctor approximately any unusual changes on your conduct and mood.

Are there any alternatives?

There are other capsules to be had to treat your situation. Some may be better acceptable for you than others. Talk to your doctor approximately other drug options that may fit for you.

Disclaimer: Health Hope has made every effort to make sure that all information is factually correct, comprehensive, and up-to-date. However, this article ought to not be used alternatively for the understanding and understanding of a certified healthcare professional. You must always consult your health practitioner or another healthcare professional before taking any medication. The drug data contained herein is subject to exchange and isn’t always meant to cover all feasible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse results. The absence of warnings or other records for a given drug does not suggest that the drug or drug aggregate is safe, powerful, or suitable for all sufferers or all precise uses.

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